He4 blodprøve What is being tested? Human epididymis protein 4 (HE4) is a protein that is produced by most, but not all, epithelial ovarian cancer cells. This makes the test useful as a tumor marker in specific circumstances. The HE4 test measures the amount of human epididymis protein 4 in the blood. 1 ca125 2 The new blood test under Barr’s investigation looks for the presence of a different protein found in the blood, called human epididymis protein 4 (HE4). Early results published in the journal Cancers in April show that analyzing HE4 alongside CA may allow for more accurate detection of ovarian cancer. 3 he4 normal range 4 endometrioide tumorer. Ved utredning har tumormarkøren HE4 (Human Epididymis protein 4) flere fordeler sammenlignet med CA Høyere sensitivitet for oppdagelse i et tidlig stadium Høyere spesifisitet fordi HE4 er sjeldnere forhøyet ved benigne svulster på eggstokkene ( eggstokkcyste eller endometriose). 5 Human epididymis protein 4 (HE4) belongs to the family of whey acidic four-disulfide core (WFDC) proteins. Currently, the biologic function of HE4 is unknown. HE4 has been shown to be overexpressed in 93% of serous, % of endometrioid, and 50% of clear cell ovarian carcinomas. 6 Background. To evaluate the diagnostic value of adding human epididymis protein 4 (HE4), cancer antigen (CA) and risk of malignancy algorithm (ROMA) to ultrasound for detecting ovarian cancer in patients with a pelvic mass. 7 cea 8 Avdeling for medisinsk biokjemi starter fra mai å analysere HE4 i rutinen. 9 Se informasjon om HE4 i Brukerhåndboken i medisinsk biokjemi, OUS. Se også for startside i Brukerhåndboken. 10 Human epididymis 4 protein. The human epididymis 4 protein (HE4) is a product of the WAP four-disulfide core domain 2 gene whose function is unknown. The HE4 gene is overexpressed in ovarian cancer, particularly in tumors of serous and endometrioid histology, but is not specific for ovarian tumors. 11